UGNLABS

Supplement Facts

Amount Per Serving

%DV

Serving Size 1 CapsuleServings Per Container 60

N-Acetyl-L-Cysteine （NAC） 500 mg

*Daily Value not established. Other ingredients: Vegetarian capsule (hydroxypropyl methycellulose, water), microrystalline cellulose, ascorbyl palmitate, and silicon dioxide.

Introduction

N-acetyl cysteine (NAC) is an amino acid that boosts antioxidant function and is a source of the conditionally essential amino acid L-cysteine. It has also been found to raise glutathione levels. Glutathione is an important antioxidant used in many different metabolic processes within the body.

Maintaining adequate levels is important to maintaining the health of the respiratory, hepatic, and immune systems. It is also important in supporting antioxidant protection of lipids and proteins and supporting the normal response to inflammation.

1. De Rosa SC, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 2000 Oct;30(10):841-2. [PMID:11029607].

2. Atkuri KR, Mantovani JJ, Herzenberg LA, et al. N-Acetylcysteine -a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Review. [PMID: 17602868].

3. Nakamura H, Masutani H, Yodoi J. Redox imbalance and its control in HIV infection. Antioxid Redox Signal. 2002 Jun;4(3):455-64. [PMID: 12215212].

4. Roberts RL, Aroda VR, Ank BJ. N-acetylcysteine enhances antibody-dependent cellular toxicity in neutrophils

and mononuclear cells from healthy adults and human immunodeficiency virus-infected patients. J Infect Dis. 1995

Dec;172(6):1492-502. [PMID: 7594708].

5. Witschi A, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43:667-9. [PMID: 1362956].

9. De Rosa SC, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 2000 Oct;30(10):841-2. [PMID: 11029607].

6. Atkuri KR, Mantovani JJ, Herzenberg LA, et al. N-Acetylcysteine -a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Review. [PMID: 17602868].

7. Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebocontrolled clinical trials. Clin Ther. 2000 Feb 22(2):209-21. [PMID:10743980].

8.Yalçin E, Altin F, Cinhüseyinoglue F, et al. N-acetylcysteine in chronic blepharitis. Cornea. 2002 Mar;21(2):164-8. [PMID: 11862087].

9. Mirhosseini SJ, Forouzannia SK, Nasirian M, Ali-Hassan- Sayegh S. Saudi J Anaesth. N-acetylcysteine instead of theophylline in patients with COPD who are candidates for elective off-pump CABG surgery: Is it possible in cardiovascular surgery unit? Saudi Journal of Anaesthesia. 2013 Apr;7(2):151-4. doi: 10.4103/1658-354X.114069.

10. Tse HN, Raiteri L, Wong KY, Yee KS, Ng LY, Wai KY, Loo CK, Chan MH. High-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE study. Chest. 2013 Jul;144(1):106-18. doi: 10.1378/chest.12-2357.

11. Chalumeau M, Duijvestijn YC. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract nfections in paediatric patients without chronic broncho-pulmonary disease. Cochrane Database Syst Rev. 2013 May 31;5:CD003124. doi: 10.1002/14651858.CD003124.pub4.

12. Jugg B, Fairhall S, Smith A, Rutter S, Mann T, Perrott R, Jenner J, Salguero J, Shute J, Sciuto AM. N-acetyl-L-cysteine protects against inhaled sulfur mustard poisoning in the large swine. Clin Toxicol (Phila). 2013 May;51(4):216-24. doi: 10.3109/15563650.2013.780208. Epub 2013 Apr 2.

13. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008 Sep;11(6):851-76. doi: 10.1017/ S1461145707008401. Epub 2008 Jan 21.

14. Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol Psychiatry. 2012 Jun 1;71(11):956-61. doi: 10.1016/j.biopsych.2012.01.014. Epub 2012 Feb 18.

Description

This derivative of the amino acid cysteine is often used as the preferred substrate for intracellular glutathione synthesis. It also assists detoxification, provides cellular antioxidant protection, and is much safer than cysteine.†

Belonging

Antionxidants(9)

Liver&Detox(9)

Indications

·Antioxidants And Cell Protectors ·Immune Health ·Inflammation Support ·Support Liver Health ·Support Lung Health

Usage

Take 1 capsule, 1 to 2 times daily or as directed by a healthcare professional. It is recommended that this product be taken with a multiple vitamin and mineral supplement.

Reminder

If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product.

Allergy Information

Free of the following common allergens: milk/ casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, corn, and yeast. Contains no artificial colors, flavors, or preservatives.

Storage Condition

Store in a cool, dry place. Use only safety seal is intact.