Gluco Support is a comprehensive blood sugar metabolism support formula that integrates herbs, minerals and alpha lipoic acid. The formula helps to reduce intestinal glucose absorption, increase insulin sensitivity in peripheral tissues, promote glucose metabolism in the body, and maintain blood sugar balance. The ingredients in the formula can also support pancreatic β-cell function and reduce diabetes complications.

Gymnema

Gymnema is a commonly used plant component in Ayurvedic medicine. It can assist the regeneration of pancreatic β-cells and increase the insulin sensitivity of peripheral tissues. Gymnema is also believed to reduce the intestinal absorption of glucose.

Momordica charantia

Momordica charantia contains at least three groups of beneficial components that have the function of regulating blood sugar, including a series of steroidal saponins called momordin, insulin-like peptides and alkaloids. Among them, the bitter melon polypeptide-P isolated from the seeds of bitter melon is called plant insulin and has an insulin-like effect. Among them, "Patent Sequence 19 Peptide (mclRBP-19)" has been proven to be the only natural peptide that can interact with insulin receptor besides insulin. It can act on different insulin receptor positions to help regulate glucose [1- 2]. The hypoglycemic mechanism of bitter melon extract includes: increasing the secretion of insulin and helping the recovery of damaged islet cells; increasing the oxidation and decomposition of glucose, activating glucose metabolism, and inhibiting the absorption of glucose in the intestine; inhibiting the key enzymes of gluconeogenesis.

Fenugreek

Fenugreek extract can promote insulin secretion, delay the absorption of glucose in the intestine, improve insulin sensitivity, and thus play a hypoglycemic effect [3].

Garcinia cambogia

The hydroxycitric acid contained in Garcinia cambogia helps to promote fat and glucose metabolism [4]. Studies have also shown that hydroxycitric acid plays an important role in regulating normal appetite.

Alpha lipoic acid

Alpha lipoic acid is an essential cofactor for carbohydrate, protein and fat metabolism. Alpha-lipoic acid also helps prevent neuropathy caused by hyperglycemia [5].

chromium

Chromium is a component of glucose tolerance factor (GTF). Adequate chromium has a positive effect on maintaining insulin sensitivity and blood glucose metabolism. Chromium can promote the maximum biological effect of insulin, can increase the utilization of glucose, and can also increase glucose transport. The improvement of blood glucose metabolism in type 2 diabetes by trivalent chromium is based on the premise of a certain degree of islet function, which has insulin resistance to high fasting blood glucose and high glycosylated hemoglobin, and has more obvious effects on lowering blood sugar and improving insulin sensitivity in patients with type 2 diabetes [6].

1. Hsu PK, Pan FFC, Hsieh CS. mcIRBP-19 of Bitter Melon Peptide Effectively Regulates Diabetes Mellitus (DM) Patients' Blood Sugar Levels. Nutrients. 2020; 12:1252.

2.Pan F, Hsu PK, Chang WH. Exploring the Factors Affecting Bitter Melon Peptide Intake Behavior: A Health Belief Model Perspective. Risk Manag Healthc Policy. 2020; 13:2219-2226.

3.Hannan JM, Ali L, Rokeya B, Khaleque J, Akhter M, Flatt PR, Abdel-Wahab YH. Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br J Nutr. 2007 Mar;97(3):514-21.

4.Semwal RB, Semwal DK, Vermaak I, et al. A comprehensive scientific overview of Garcinia cambogia. Fitoterapia. 2015;102:134-148.

5.allianou N, Evangelopoulos A, Koutalas P. Alpha-lipoic Acid and diabetic neuropathy. Rev Diabet Stud. 2009;6(4):230-236. doi:10.1900/RDS.2009.6.230.

6. Albarracin CA, Fuqua BC, Rvans JL, Goldfine ID. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes Diabetes. Metab Res Rev. 2008; 24: 41-51.